By Ah-Ng Tony Kong
Increasing medical facts means that nearly all of ailments together with melanoma are pushed by way of oxidative tension and irritation, attributed to environmental elements. those elements both force genetic mutations or epigenetically regulate expression of key regulatory genes. those alterations can ensue as early as gestational fetal improvement, and significant questions stay as to how dietary/nutritional phytochemical elements biochemically have interaction with such genetic and epigenetic occasions. With chapters written via foreign specialists, Inflammation, Oxidative pressure, and melanoma: nutritional techniques for melanoma Prevention examines the newest advancements at the results of varied nutritional phytochemicals.
Divided into 9 sections, the publication starts with the elemental mechanisms of inflammation/oxidative stress-driven melanoma, together with an outline of the subject and the way to avoid carcinogenesis, the position of weight problems in irritation and melanoma, and antioxidant houses of a few universal nutritional phytochemicals. next sections hide mobile sign transduction, molecular goals, and biomarkers of nutritional cancer-preventive phytochemicals, in addition to their capability demanding situations with in vivo absorption and pharmacokinetics.
The chapters additionally learn the cancer-preventive houses of assorted sessions of phytochemicals, together with supplements A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, conventional chinese language natural medicinal drugs, and alpha lipoic acid. the ultimate component to the publication explores the most recent advancements at the interactions of nutritional phytochemicals via epigenetics and the administration of persistent irritation with dietary phytochemicals.
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Additional info for Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention
Jang, J. , and Y. J. Surh. 2001. Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells. Mutation Research—Genetic Toxicology and Environmental Mutagenesis 496 (1–2):181–190. , R. Siegel, E. Ward, Y. Hao, J. Xu, and M. J. Thun. 2009. Cancer Statistics, 2009. CA: A Cancer Journal for Clinicians 59 (4):225–249. Jeong, W. , M. Jun, and A. N. Kong. 2006. Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxidants and Redox Signaling 8 (1–2):99–106.
Formation of heterocyclic amines using model systems. Mutation Research 259 (3–4):219–233. Jang, J. , and Y. J. Surh. 2001. Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells. Mutation Research—Genetic Toxicology and Environmental Mutagenesis 496 (1–2):181–190. , R. Siegel, E. Ward, Y. Hao, J. Xu, and M. J. Thun. 2009. Cancer Statistics, 2009. CA: A Cancer Journal for Clinicians 59 (4):225–249. Jeong, W. , M. Jun, and A. N. Kong. 2006. Nrf2: a potential molecular target for cancer chemoprevention by natural compounds.
SFN reacts with the thiol groups of Keap1 to form thionoacyl adducts (Hong, Freeman, and Liebler 2005). A combination of curcumin and PEITC significantly reduced the growth of PC-3 xenografts. PEITC inhibited the Akt and NF-κB signaling pathways, leading to inhibition of proliferation and induction of apoptosis (Khor et al. 2006). Azoxymethane (AOM)/ Dextran sulfate sodium (DSS) mice fed a PEITC- or dopamine-betamonooxygenase (DBM)supplemented diet had lower tumor incidences, lower colon tumor multiplicities, and smaller polyps, as compared to mice fed with the standard AIN-76A diet (Cheung et al.
Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention by Ah-Ng Tony Kong