By H. A. Offe (auth.), Professor Dr. med. Karl Bartmann (eds.)
This quantity bargains particularly with these antituberculosis medications which handed the preclinical part and feature been or are utilized in the therapy of tuberculosis and different mycobacterial illnesses (except leprosy) in no less than a few elements of the realm. regardless of this restrict, there are 14 such medicines, and for this reason this quantity has reached quite huge proportions. to avoid it from changing into even better and extra unwidely, so much derivatives of antituberculotics were passed over, in particular the place it truly is claimed that they supply purely greater bioavailibility or tolerability. simply within the bankruptcy at the chemotherapy of illnesses as a result of so-called peculiar mycobacteria is the scientific use of the medicine defined to a undeniable quantity. as well as antituberculotics, additionally mentioned are antimicrobials that have been discovered to be powerful opposed to those mycobacteria. The series during which the medication are defined is old, reflecting now not the time of discovery yet fairly the 1st medical program. This order was once chosen for purposes that are now not correct. during this quantity much less emphasis is put on detection, organic or artificial creation of antituberculotics, and structure-activity relationships. against this, emphasis is wear the measure, kind, and mechanism of antimyco bacterial job, pharmacokinetics, and biotransformation in animals and guy, on experimental pharmacodynamics, and at the toxicity of antituberculotics used therapeutically.
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There is a very wide variety of chemical detection and determination methods, some of which are also used for metabolite determinations. A detailed summary has been given by OTTEN et al. (1975). Techniques used in the last years are polarography (SUSHKIN and GUZEEVA 1978) and gaschromatography (FRATER-SCHRODER and ZBINDEN 1976) or gaschromatography combined with mass spectrometry (LAUTERBURG et al. 1981). INH forms complexes with many heavy metal salts. It reduces ammoniacal silver salt solutions yielding silvered mirrors.
Arzneim Forsch 21:1908-1969 De Boer C, Meulman PA, Wnuk RJ, Peterson DH (1970) Geldanamycin, a new antibiotic. J Antibiot 23:442-447 Eidus L, Ling GM, Harnanansingh AMT (1969) Laboratory investigation of rifampin. Int J Clin Pharmacol 2:296--299 Eidus L, Harnanansingh AMT (1969) Simple procedures for checking rifampin in urine. Am Rev Resp Dis 100:738-739 Kishi T, Asai M, Muroi M, Harada S, Mizuta E, Terao E, Miki T, Mizuno K (1969) Tolypomycin. I. lycinone. Tetrahedron Letters No 2:91-95 Liittringhaus A, Gralheer H (1942) Uber eine neue Art atropisomerer Verbindungen.
6°. 2). The free base is reported as being readily soluble in chloroform, while the hydrochloride is readily soluble in water. The aqueous solution is thermostable and can be kept for a long time without decomposition. In a thin-layer chromatogram (n-propanol, ammonia, water), EMB can be visualized as a blue spot by a mixture of 10% aqueous solutions of sodium nitroprusside, sodium carbonate, and acetaldehyde (1: 1: 1) (REUTGEN and GRUNERT 1969). For spectrophotometric determination in pharmaceutical products and in urine, the formation of a copper complex with Folin's reagent and measurement of the absorption at 265 nm or 610 nm have been recommended (REUTGEN and GRUNERT 1969).
Antituberculosis Drugs by H. A. Offe (auth.), Professor Dr. med. Karl Bartmann (eds.)