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By Bruce C Baguley; David J Kerr

ISBN-10: 0120726513

ISBN-13: 9780120726516

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In this way, increased activity of cycA:cdk2 may serve to terminate E2F activity at the end of S phase. , ...... , ........ , .................... psz,+ ~ ~ | + [2 ............ + ........... l++l (ATe} . . . ', F I ................................................... :I '............................................... ~ i .............. 1 . I......... ++,. ~ +~. 115', pszo +I++5,+3 ]< m*-I--~-(- + " I~"+ .... ~ ... I + .... lco, ....... ++ ~o~o+ +o(:~, .... I ............. ::. CHAPTER 2, FIGURE 3 Molecular interaction map of the control of the G2-M cell cycle phase transition.

Gilbert, J. , Paielli, D. , Kim, J. , Heise, C. , and Kirn, D. H. (2000). In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy. Cancer Res. 60, 1193–1196. Rosania, G. , Chang, Y. , Schultz, P. , and Heald, R. (1999). A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc. Natl. Acad. Sci. USA 96, 4797–4802. , Whitaker, N. , and zur Hausen, H. (1998). Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.

M. (1998). UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase. J. Biol. Chem. 273, 33455–33464. Zaharevitz, D. , Senderowicz, A. , and Sausville, E. A. (1999). Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 59, 2566–2569. Zhao, H. and Piwnica-Worms, H. (2001). Atr-mediated checkpoint pathways regulate phosphorylation and activation of human chk1.

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Anticancer drug development by Bruce C Baguley; David J Kerr


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