Annual Reports in Medicinal Chemistry, 3 by C K Cain PDF

By C K Cain

ISBN-10: 0080583474

ISBN-13: 9780080583471

ISBN-10: 0120405032

ISBN-13: 9780120405039


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Using a similar approach, - - Chap. 2 Stimulants 21 - Davi s (-)a a Swiss group developed a one-step preparation of 'lo and quantitatively isomerised it to 'I1. 1T9ese workers also developed a direct preparation of (-)-cannabidiol (33) which could readily be converted to or (-)% (cf. ref. 109): A two-step synthesis of (-)31 involving resolution of an intermediate (3 4)'13 and a somewhat lengthypreparation of dl-3J and '14 were reported. The unnatural (+)-enantiomor h of 31 was prepared 13,113 and found to be devoid of ataxic activity lo'.

17, 242 (1967). 33. J. N. Sinha, R. C. Srimal, B. P. J a j u and K. P. Bhargava, Arch. Int. Pharmacodyn. Ther. 165(1), 160 (1967). 34. S. R. Dasgupta and G. Werner, Arch. Int. Pharmacodyn. Ther. 100, 409 (1955). 3 5. E. M. Keary and D. R. Maxwell, Brit. J. Pharmacol. Zq, 400 (1967). 36. P. D. Wall, Anesthesiology 28(1), 46 (1967). 37. J. C. Krantz, Jr. , Bull. School Med. Univ. Maryland 52 ( l ) , 12 (1967). 38. P. Chodoff and J. G. Stella, Anesthesia Analgesia, C u r r e n t Res. 45, 527 (1966).

Steward, - - - - - - - - D ep r e s sant s Chap. 3 Lun sfo r d 19. R. M. G e s l e r , C. E. Lintz and E. A. Swinyard, Toxicol Appl. Pharmacol. 3, 107 (1961). 20. E. R. Wagn; and A. D. Rudzik, J. Med. Chem. 10, 607 (1967). 21. C. R. Craig, Arch. Int. Pharmacodyn. Ther. 1657328 (1967). 22. T. J. Schwan, J. F. Holland and H. Tickelmann, J. Heterocycl. Chem. 1, 299 (1964). 23. R. B a n z g e r and D. Hane, Arch. Int. Pharmacodyn. Ther. 167, 245 (1967). 24. E. B. Schlesinger and L. P. Rowland in "Drugs of Choice", W.

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